1. Sato S., Zamami Y., Imai T., Tanaka S., Koyama T., Nimura T., Chuma M., Koga T., Takechi K., Kondo Y., Izawa-Ishizawa Y., Sendo T., Nakura H., Isizawa K. Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia. Sci. Rep. 7(1):12683. doi: 10.1038/s41598-017-13073-0. 2017.
  2. Koyama T., Zamami Y., Oshima A., Teratani Y., Shinomiya K., Kitamura Y. Pattern of CT use in Japan, 2014: A nationwide cross-sectional study. Eur. J. Radiology 97: 96-100, 2017.
  3. Gomita Y, Esumi S, Kitamura Y, Motoda H, Sendo T, Sagara H, Araki H, Mio M, Inoue S, Kano Y. Intracranial self-stimulation and immobilization had different effects on neurite extension and the p38 MAPK pathway in PC12m3 cells. Life Sci. 190: 78-83, 2017.
  4. Tsuge M., Hazama K., Kanzaki H., Itano Y., Maeshima K., Oucida M., Nakatsuka H. Development of a novel analgesic for cancer pain targeting brain-derived neurotrophic factor.  Kawasaki Medical Journal  (in press)
  5. Hirayama T., Nosaka N., Okawa Y., Ushio S., Kitamura Y., Sendo T., Ugawa T., Nakao A. AN69ST membranes adsorb nafamostat mesylate and affect the management of anticoagulant therapy: a retrospective study. J. Intensive Care 5:46 DOI 10.1186/s40560-017-0244-x
  6. Higuchi H., Inagaki M., Koyama T., Kitamura Y., Sendo T., Fujimori M., Kataoka H., Hayashibara C., Uchitomi Y., Yamada N. Emotional intelligence and its effect on pharmacist and pharmacy students with autistic-like traits. Am. J. Pharm. Educ. 71: 4 Article 74, 2017.
  7. Kudo K., Ohashi K., Makimoto G., Higo H., Kayatani H., Kurata Y., Takami Y., Minami D., Ninomiya T., Kubo T., Ichihara E., Sato A., Hotta K., Yoshino T., Tanimoto M., Kiura K. Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo. Mol. Oncol. doiI: 10.1002/1878-0261.12063, 2017
  8. Gomita Y, Esumi S, Sugiyama N, Kitamura Y, Koike Y, Motoda H, Sendo T, Kano Y. Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. Neurosci. Lett. 649: 78-84, 2017
  9. Kawaura A., Kitamura Y., Tanida N., Akiyama J., Mizutani M., Harada K., Morishita M., Inoue S., Kano Y., Okano T., Takeda E. Antidepressant-like effect of 1α-hydroxyvitamin D3 on mice in the forced swimming test. J. Nutr. Sci. Vitaminol. 63: 81-84, 2017
  10. Kitamura Y., Kanemoto E., Sugimoto M., Machida A., Nakamura Y., Naito N., Kanzaki H., Miyazaki I., Asanuma M., Sendo T. Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats. Naunyn Schmiedebergs Arch Pharmacol. 390: 369-378, 2017
  11. Kikkawa A., Kitamura Y., Aiba T., Hiraki K., Sendo T. Correlation between the efficacy of lamotrigine and the serum lamotrigine level during the remission phase of acute bipolar II depression: A naturalistic and unblinded prospective pilot study. Biol. Pharm. Bull. 40: 413-418, 2017
  12. Takeda T., Yamamoto H., Kanzaki H., Suzawa K., Yoshioka T., Tomida S., Cui X., Murali R., Namba K., Sato H., Torigoe H., Watanabe M., Shien K., Soh J., Asano H., Tsukuda K., Kitamura Y., Miyoshi S., Sendo T., Toyooka S. Yes1 signaling mediates the resistance to trastuzumab/lapatinib in breast cancer. PLOS ONE 12(2):e0171356. doi: 10.1371/journal.pone.017135, 2017.
  13. Matsuyama A., Takatori S., Sone Y., Ochi E., Goda M., Zamami Y., Hashikawa-Hobara N., Kitamura Y., Kawasaki H. Effect of nerve growth factor on innervation of perivascular nerves in neovasculatures of mouse cornea. Biol. Pharm. Bull. 40: 396-401, 2017
  14. Sone Y., Takatori S., Ochi E., Zamami Y., Matsuyama A., Fukuhara S., Goda M., Kitamura Y., Kawasaki H. Nerve Growth Factor Facilitates the Innervation of Perivascular Nerves in Tumor-Derived Neovasculature in the Mouse Cornea. Pharmacology 99: 57-66, 2017


  1. Isozaki H, Hotta K, Ichihara E, Takigawa N, Ohashi K, Kubo T, Ninomiya T, Ninomiya K, Oda N, Yoshioka H, Ichikawa H, Inoue M, Takata I, Shibayama T, Kuyama S, Sugimoto K, Harada D, Harita S, Sendo T, Tanimoto M, Kiura K. Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non-Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405). Clin Lung Cancer 17: 602-605, 2016
  2. Zamami Y, Imai T, Imanishi M, Takechi K, Shiraishi N, Koyama T, Sagara H, Shiino Y, Nakura H, Sendo T, Ishizawa K. Evaluation of a Pharmaceutical Life-saving Skills Training Program using the Customer Satisfaction Analysis. Journal of Pharmaceutical Health Care and Sciences 2:21, 2016 DOI 10.1186/s40780-016-0054
  3. Ishida H., Kanamitsu K., Washio K., Muraoka M., Sakakibara K., Matsubara T., Kanzaki H., Shimada A. Relapsed infant MLL-rearranged acute lymphoblastic leukemia with additional genetic alterations. Pediatr Blood Cancer 2016 DOI 10.1002/pbc.26100
  4. Isozaki H, Ichihara E, Takigawa N, Ohashi K, Ochi N, Yasugi M, Ninomiya T, Yamane H, Hotta K, Sakai K, Matsumoto K, Hosokawa S, Bessho A, Sendo T, Tanimoto M, Kiura K. Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases. Cancer Res. 76: 1506-1516, 2016
  5. Higuchi Y, Inagaki M, Koyama T, Kitamura Y, Sendo T, Fujimori M, Uchitomi Y, Yamada N. A cross-sectional study of psychological distress, burnout, and the associated risk factors in hospital pharmacists in Japan. BMC Public Health. 6:534, 2016
  6. Tsuboi C., Kawasaki Y., Yoshitome K., Yagi K., Miura T., Esumi S., Miyazaki I., Asanuma M., Kitamura Y., Sendo T. In vitro quantitative determination of the concentration of the polymerization agent methyl 2-benzoylbenzoate in intravenous injection solution and the cytotoxic effects of the chemical on normal human peripheral blood mononuclear cells. Environ Sci Pollut Res 23: 10262-10269, 2016
  7. Miyazaki I., Murakami S., Torigoe N., Kitamura Y., Asanuma M. Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian model mice. J. Neurochem. 136: 194-204, 2016
  8. Kanzaki H., Mukhopadhya NK., Cui X, Ramanujan VK., Murali R. Trastuzumab-Resistant Luminal B Breast Cancer Cells Show Basal-Like Cell Growth Features Through NF-κB-Activation. Monoclon Antib Immunodiagn Immunother. 35: 1-11, 2016


  1.  Murakawa K., Kitamura Y., Watanabe S., Hongo S., Shinomiya K., Sendo T.:  Clinical Risk Factors Associated with Postoperative Delirium and Evaluation of Delirium Management and Assessment Team in Surgical Patients. Journal of Pharmaceutical Health Care and Sciences 1:4 (2015) DOI 10.1186/s40780-014-0002-3
  2. Kajizono M., Aoyagi M., Kitamura Y., Sendo T. Effectiveness of the medical supportive team for outpatients treated with sorafenib. Journal of Pharmaceutical Health Care and Sciences 1:6 (2015) DOI 10.1186/s40780-014-0005-0
  3. Kurata Y., Miyauchi N., Suno M., Ito T., Sendo T., Kiura K. Correlation of plasma crizotinib trough concentration with adverse events in patients with anaplastic lymphoma kinase positive non-small-cell lung cancer. Journal of Pharmaceutical Health Care and Sciences 1:8 (2015) DOI 10.1186/s40780-014-0008-x
  4. Kawasaki Y., Tuboi C., Yagi K., Morizane M., Masaoka Y., Esumi S., Kitamura Y., Sendo T.. Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro. Environmental Science and Pollution Research 22: 4763-4770, 2015
  5. Suno M., Endo Y., Nishie H., Kajizono M., Sendo T., Matsuoka J. Refractory cachexia is associated with increased plasma concentrations of fentanyl in cancer patients. Therapeutics and Clinical Risk Management. 11: 751-757, 2015
  6. Tsutsui T., Shinomiya K., Sendo T., Kitamura Y., Kamei C. Effects of the 5-HT1A receptor agonist tandospirone on ACTH-induced sleep disturbance in rats. Biol. Pharm. Bull. 38: 884-888, 2015
  7. Kitamura Y., Hattori S., Yoneda S., Watanabe S., Kanemoto E., Sugimoto M., Kawai T., Machida A., Kanzaki H., Miyazaki I., Asanuma M., Sendo T. Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation. Behav. Brain Res. 292: 184-193, 2015
  8. Hagiya H., Tasaka K., Sendo T., Otsuka F. Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection. Infect Drug Resist. 8: 353-357, 2015
  9. Kajizono M., Sada H., Sugiura Y., Soga Y., Kitamura Y., Matsuoka J., Sendo T. Incidence and risk factors of osteonecrosis of the jaw in advanced cancer patients after treatment with zoledronic acid or denosumab: a retrospective cohort study. Biol. Pharm. Bull. 38: 1850-1855, 2015
  10. Higuchi Y., Uchitomi Y., Fujimori M., Koyama T., Kataoka H., Kitamura Y., Sendo T., Inagaki M. Exploring autistic-like traits relating to empathic attitude and psychological distress in hospital pharmacists. Int. J. Clin. Pharm. 37: 1258-1266、2015
  11. Morizane M., Kawasaki Y., Miura T., Yagi K., Esumi S., Kitamura Y., Sendo T. Photoinitiator-initiated estrogenic activity in human breast cancer cell line MCF-7. J. Toxicol. Environ. Health A. 78: 1450-1460, 2015


  1. Onoue Y., Kuwatsuka K., Miyazaki I., Asanuma M., Kitamura Y., Sendo T.:  Effects of bupropion and pramipexole on cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats. Biol. Pharm. Bull 37: 327-330, 2014
  2. Yagi Y., Kawasaki Y., Nakamura H., Miura T., Esumi S., Matsunaga H., Kitamura Y., Sendo T.. Differential synergistic effect of COX inhibitors on cell survival suppressed by Sorafenib in hepatocellular cancer cells. Biol. Pharm. Bull. 37: 1234-1240, 2014
  3. Miyake A., Kitamura Y., Miyazaki I., Asanuma M., Sendo T. Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats. Pharmacol. Biochem, Behav. 122: 240-245, 2014
  4. Tomotsuka N., Kaku R., Obata N., Matsuoka Y., Kanzaki H., Taniguchi A., Muto N., Omiya H., Itano Y., Sato T., Ichikawa H., Mizobuchi S., Morimatsu H. Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model. J. Pain Res. 7: 415-423, 2014
  5. Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K. A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene. Jpn. J. Clin. Oncol. 44: 963-968, 2014
  6. Kitamura Y, Hayashi H, Onoue Y, Kuwatsuka K, Miyake A, Miyazaki I, Asanuma M, Sendo T. Effects of imipramine and lithium on the expression of hippocampal Wnt 3a and cyclin D1 in ACTH-treated rats. Journal of Behavioral and Brain Sciences 4: 483-490, 2014


  1. Murakawa K., Sato T., Maeda Y., Kitamura Y., Tanimoto M., Sendo T. Preparation of Enteric-coated Capsules of Beclomethasone Dipropionate for Patients with Intestinal Graft-Versus-Host Disease and a Case Study. Acta Med Okayama 67: 319-324, 2013
  2. Kuwatsuka K., Hayashi H., Onoue Y., Miyazaki I., Koyama T., Asanuma M., Kitamura Y., Sendo T. The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats. J. Pharmacol. Sci. 122: 34-41, 2013
  3. Kawasaki Y., Yagi K., Tsuboi C., Morizane M., Kitamura Y., Sendo T. The polymerization agent, 2-methyl-4’-(methylthio)-2-morpholinopropiophenone induces caspases-3/7 in human blood mononuclear cells in vitro. Biol. Pharm. Bull. 36: 1640-1645, 2013
  4. Miyazaki I., Asanuma M., Murakami S., Takeshima M., Torigoe N., Kitamura Y. Miyoshi, K. Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models. Neurobiol. Dis. 59:244-256, 2013
  5. Esumi S., Kawasaki Y., Nakamoto A., Sagara H., Kitamura Y., Gomita Y., Sendo T. : Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation Eur. J. Pharmacol. 720:186-191、2013
  6. Li B, Suemaru K., Kitamura Y., Gomita Y., Araki H., Cui R. Imipramine-induced c-Fos expression in the medial prefrontal cortex is decreased in the ACTH-treated rats. J. Biochem. Molecular Toxicology  27:486-491, 2013


  1. Kawasaki Y., Yamaji K., Matsunaga H., Sendo T.: Cytotoxicity of the Polymerization Agent, 2-Methyl-4′-(methylthio)-2-morpholinopropiophenone on Human Monocytes. Biol. Pharm. Bull, 35(2):256-9, 2012.
  2. Tamaki C., Nawa H., Takatori S., Oda S., Sendo T., Zamami Y., Y., Kawasaki H.: Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilation in the rat mesenteric vascular bed. J. Pharmacol. Sci. 118(4):496-505, 2012.
  3. Ishihara M., Ikesue H., Matsunaga H., Suemaru K., Kitaichi K., Suetsugu K., Oishi R., Sendo T., Araki H., Itoh Y., A multi-institutional study evaluating the effects of laxatives and antiemetics for preventing opioid-induced adverse events. Clin. J. Pain. 28(5):373-381, 2012.
  4. Jobu K., Sun C., Yoshioka S., Yokota J., Onogawa M., Kawada C., Inoue K., Shuin T., Sendo T., Miyamura M. : Metabonomic study on the biochemical profiles of odor elements in urine of human bladder cancer., Biol. Pharm. Bull. 35(4):639-42, 2012.
  5. Kajizono M., Saito M., Maeda M., Yamaji K., Fujiwara S., Kawasaki Y., Matsunaga H., Sendo T.: Cetuximab-induced skin reactions are suppressed by cigarette smoking in patients with advanced colorectal cancer. Int J Clin Oncol, in press, 2012
  6. Yamaji K., Kawasaki Y., Yoshitome K., Matsunaga H., Sendo T.: Quantitation and cytotoxicity on human monocytes of 1-hydroxycyclohexy-phenyl ketone (Irgacure 184) in water injection between three brands. Biol. Pharm. Bull. 35(10): 1821-1825, 2012.


  1. Ueshima, S., Aiba, T., Sato, T., Matsunaga, H., Kurosaki, Y., Ohtsuka,Y. and Sendo,
    T. Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development.
    Biol. Pharm. Bull., 34(1): 108-113, 2011


  1. Ueshima, S., Aiba, T., Ishikawa, N., Sato, T., Kawasaki, H., Kurosaki, Y., Ohtsuka, Y. and Sendo, T.: Poor applicability of estimation method for adults to calculate unbound serum concentrations of valproic acid in epileptic neonates and infants. J. Clin. Pharm. Ther, 34: 415-422, 2009


  1. Kawasaki, Y., Matsuka, N., Okada, T., Kawashima, R., Kitagawa, N., Sendo, T. and Gomita, T. :Examination of particulate contamination after ampoule opening- Relationship between ampoule inner-diameter and glass particle accumulation after opening-. Jpn. J. Pharm. Health. Care Sci. 34(11): 1032-1036, 2008
  2. Maiguma, T., Hayashi, Y., Ueshima, S., Kaji, H., Egawa, T., Chayama, K., Morishima, T., Kitamira, Y., Sendo, T., Gomita, Y. and Teshima, D.: Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia. Int J. Clin Pham. Ther., 46(11): 584-590, 2008
  3. Ishii, M., Kawakami, Y., Date, H., Higaki, K., Sendo, T and Kimura, T.: Correlation of cyclosporine blood concentration-dose ratio and biochemical parameters in living-donor lung transplant patients. Jpn. J. Pharm. Health. Care Sci., 34: 381-385, 2008
  4. Ueshima, S., Aiba, T., Makita, T., Nishihara, S., Kitamura, Y., Kurosaki,Y., Kawasaki, H., Sendo, T., Ohtsuka Y. and Gomita. Y.: Characterization of nonlinear relationship between total and unbound serum concentration of valproic acid in epileptic children. J. Clin. Pharm. Ther, 33: 31-38, 2008


  1. Kawakami Y, Kitamura Y, Araki H, Kitagawa K, Suemaru K, Shibata K, Gomita Y.
    Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats. Pharmacol Biochem Behav. 2005, 81(1): 65-70.
  2. Motoshima S, Suemaru K, Kawasaki Y, Jin C, Kawasaki H, Gomita Y, Araki H.
    Effects of alpha4beta2 and alpha7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats. Eur J Pharmacol. 2005, 519(1-2): 91-95.


  1. Watanabe K, Matsuka N, Okazaki M, Hashimoto Y, Araki H, Gomita Y. The effect of immobilization stress on the pharmacokinetics of omeprazole in rats. Acta Med Okayama. 2002, 56(1): 19-23.