1. Morio K, Kurata Y, Kawaguchi-Sakita N, Shiroshita A, Kataoka Y.:Efficacy of Metformin in Patients With Breast Cancer Receiving Chemotherapy or Endocrine Therapy: Systematic Review and Meta-analysis. Ann Pharmacother. June 17, 2021. doi: 10.1177/10600280211025792. (in Press)
  2. Matsumoto D, Ushio S, Wada Y, Noda Y, Esumi S, Izushi Y, Kitamura Y, Sendo T.:Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice. Eur. J. Pharmacol.(in Press)
  3. Kishi T, Sakuma K, Okuya M, Matsuda Y, Esumi S, Hashimoto Y, Hatano M, Miyake N, Miura I, Mishima K, Iwata N.: Effects of a conventional mood stabilizer alone or in combination with second-generation antipsychotics on recurrence rate and discontinuation rate in bipolar I disorder in the maintenance phase: A systematic review and meta-analysis of randomized, placebo-controlled trials. Bipolar Disord. 2021 Feb 9. doi: 10.1111/bdi.13053. (Online ahead of print.)
  4. Tsukahara H, Higashionna T, Tsuge M, Miyamura J, Kusano N.: Coronavirus disease 2019 in Okayama Prefecture: Looking back and looking forward. Global Health & Medicine (in Press).


  1. Tatebe Y, Kanamitsu Y, Kanzaki H, Ishida H, Fujiwara K, Washio K, Kitamura Y, Sendo T, Shimada A, Tsukahara H.: Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance. Acta Medica Okayama 74: 545-550, 2020.
  2. Kikuoka R, Miyazaki I, Kubota N, Maeda M, Kagawa D, Moriyama M, Sato A, Murakami S, Kitamura Y, Sendo T, Asanuma M.: Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection. Scientific Reports. Nov 26;10(1):20698. doi: 10.1038/s41598-020-77652-4.
  3. Kitamura Y, Ushio S, Sumiyoshi Y, Wada Y, Miyazaki I, Asanuma M, Sendo T.: N-acetylcysteine attenuates the anxiety-like behavior and spatial cognition impairment induced by doxorubicin and cyclophosphamide combination treatment in rats. Pharmacology. 2020 Dec 22;1-8. doi: 10.1159/000512117.
  4. Gomita Y, Esumi S, Ushio S, Kitamura Y, Sendo T, Motoda H, Inoue S, Araki H, Kano Y.: Intracranial self-stimulation-reward or immobilization-aversion had different effects on neurite extension and the ERK pathway in neurotransmitter-sensitive mutant PC12 cells. Behav Brain Res. 2020 Sep 20. doi: 10.1016/j.bbr.2020.112920.
  5. Kameda S, Kitamura Y, Masaoka Y, Fujimoto M, Ushio S, Sendo T.: Investigation of the difficulties experienced by pharmacists in Japan when communicating with cancer patients. J Clin Pharm Ther. 2020 Sep 25. doi: 10.1111/jcpt.13278
  6. Sada H, Kajizono M, Ushio S, Esumi S, Kitamura Y, Sendo T.: The Efficacy and Safety of Lubiprostone for Constipation in Cancer Patients Compared with Non-cancer Patients: A Retrospective Cohort Study. Biol Pharma Bull. 43: 1699-1706, 2020.
  7. Takahashi K, Kitamura Y, Ushio S, Sendo T.:Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model. Acta Medica Okayama 74: 301-306, 2020.
  8. Masaoka Y, Kawasaki Y, Kikuoka R, Ogawa A, Esumi S, Wada Y, Ushio S, Kitamura Y, Sendo T.: Development of an appropriate simple suspension method for valganciclovir medication. Journal of Pharmaceutical Health Care and Sciences. 6,  2020. https://doi.org/10.1186/s40780-020-00172-w
  9. Miyauchi S, Shien K, Takeda T, Araki K, Nakata K, Miura A, Takahashi Y, Kurihara E, Ogoshi Y, Namba K, Suzawa K, Yamamoto H, Okazaki M, Soh J, Tomida S, Yamane M, Sakaguchi M, Toyooka S.: Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation. Anticancer Res . 2020 May;40(5):2667-2673. doi: 10.21873/anticanres.14237.
  10. Koyama T, Hagiya H, Teratani Y, Tatebe Y, Ohshima A, Adachi M, Funahashi T, Zamami Y, Tanaka HY, Tasaka K, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Kano MR.: Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013-2015): A retrospective Observational Study. J Infect Chemother. 26: 660-660, 2020. pii: S1341-321X(20)30042-8. doi: 10.1016/j.jiac.2020.02.001.
  11. Koyama T, Hagiya H, Funahashi T, Zamami Y, Yamagishi M, Onoue H, Teratani Y, Mikami N, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Kano MR.: Trends in Place of Death in a Super-Aged Society: A Population-Based Study, 1998-2017. J Palliat Med. 23: 950-956, 2020. doi: 10.1089/jpm.2019.0445.


  1. Takenoshita S, Terada S, Oshima E, Yamaguchi M, Hayashi S, Hinotsu K, Esumi S, Shinya T, Yamada N.: Clinical characteristics of elderly depressive patients with low metaiodobenzylguanidine uptake. Psychogeriatrics. 2019 Nov;19(6):566-573. doi: 10.1111/psyg.12439.
  2. Oya K, Sakuma K, Esumi S, Hashimoto Y, Hatano M, Matsuda Y, Matsui Y, Miyake N, Nomura I, Okuya M, Iwata N, Kato M, Hashimoto R, Mishima K, Watanabe N, Kishi T.: Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design. Neuropsychopharmacol Rep. 2019 Sep;39(3):241-246. doi: 10.1002/npr2.12056.
  3. Koyama T, Sasaki M, Hagiya H, Zamami Y, Funahashi T, Ohshima A, Tatebe Y, Mikami N, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Kano MR.: Place of death trends among patients with dementia in Japan: a population-based observational study. Sci Rep. 2019 Dec 27;9(1):20235. doi: 10.1038/s41598-019-56388-w.
  4. Takeda T, Yamamoto H, Suzawa K, Tomida S, Miyauchi S, Araki K, Nakata K, Miura A, Namba K, Shien K, Soh J, Shien T, Kitamura Y, Sendo T, Toyooka S.: YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers. Cancer Sci. 2019 Dec 19. doi: 10.1111/cas.14289.
  5. Isooka N, Miyazaki I, Kikuoka R, Wada K, Nakayama E, Shin K, Yamamoto D, Kitamura Y, Asanuma M.: Dopaminergic neuroprotective effects of rotigotine via 5-HT1A receptors: Possibly involvement of metallothionein expression in astrocytes. Neurochem Int. 2019 Nov 22:104608. doi: 10.1016/j.neuint.2019.104608.
  6. Hagiya H, Koyama T, Zamami Y, Tatebe Y, Funahashi T, Shinomiya K, Kitamura Y, Hinotsu S, Sendo T, Rakugi H, Kano MR.: Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. BMJ Open. 2019 Dec 11;9(12):e033462. doi: 10.1136/bmjopen-2019-033462.
  7. Ohshima A, Koyama T, Ogawa A, Zamami Y, Tanaka HY, Kitamura Y, Sendo T, Hinotsu S, Miller MW, Kano MR.: Oral anticoagulants usage in Japanese patients aged 18-74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data. Fam Pract. 2019 Nov 18;36(6):685-692. doi: 10.1093/fampra/cmz016.
  8. Tatebe Y, Koyama T, Mikami N, Kitamura Y, Sendo T, Hinotsu S.: Hypoglycemia associated with pivalate-conjugated antibiotics in young children: A retrospective study using a medical and pharmacy claims database in Japan. J Infect Chemother. 2019 Aug 7. pii: S1341-321X(19)30217-X. doi: 10.1016/j.jiac.2019.07.013.
  9. Ohshima A, Koyama T, Ogawa A, Zamami Y, Tanaka HY, Kitamura Y, Sendo T, Hinotsu S, Miller MW, Kano MR.: Oral anticoagulants usage in Japanese patients aged 18-74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data. Fam Pract. 2019 Apr 23. pii: cmz016. doi: 10.1093/fampra/cmz016.
  10. Makita T, Kanzaki H, Onishi H, Ikeda A, Takaki A, Wada N, Takeuchi Y, Yasunaka T, Ikeda F, Shiraha H, Tanaka Y, Nishihara S, Murakawa K, Kitamura Y, Okada H, Sendo T.: Adefovir dipivoxil-induced fanconi’s syndrome and osteomalacia following multiple bone fractures in a patient with chronic hepatitis B. Yakugaku Zasshi, 139: 641-645, 2019
  11. Namba K, Tomida S, Matsubara T, Takahashi Y, Kurihara E, Ogoshi Y, Yoshioka T, Takeda T, Torigoe H, Sato H, Shien K, Yamamoto H, Soh J, Tsukuda K, Toyooka S.: Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma. BMC Cancer. 2019 Feb 26;19(1):175. doi: 10.1186/s12885-019-5374-1.
  12. Namba K, Shien K, Takahashi Y, Torigoe H, Sato H, Yoshioka T, Takeda T, Kurihara E, Ogoshi Y, Yamamoto H, Soh J, Tomida S, Toyooka S.: Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells. Mol Cancer Res. 2019 Feb;17(2):499-507. doi: 10.1158/1541-7786.MCR-18-0628.
  13. Miyazaki I., Isooka N., Wada K., Kikuoka R., Kitamura Y., Asanuma M. Effects of enteric environmental modification by coffee components on neurodegeneration in the rotenone-treated mice. Cells 2019, 8, 221; doi:10.3390/cells8030221
  14. Asanuma M., Okumura-Torigoe N., Miyazaki I., Murakami S., Kitamura Y., Sendo T.: Region-specific neuroprotective features of astrocytes against oxidative stress induced by 6-hydroxydopamine. Int. J. Mol. Sci. 20(3): 598, 2019. doi:10.3390/ijms20030598
  15. Teratani Y., Hagiya H., Koyama T., Ohshima A., Zamami Y., Tatebe Y., Tasaka K., Shinomiya K., Kitamura Y., Sendo T., Hinotsu S., Kano MR.: Association between rapid antigen detection tests and antibiotics for acute pharyngitis in Japan: A retrospective observational study. J. Infect. Chemother. 2019 Jan 11. pii: S1341-321X(18)30475-6. doi: 10.1016/j.jiac.2018.12.005.
  16. Kitamura Y., Hongo S., Yamashita Y., Yagi S., Otsuki K., Miki A., Okada A., Ushio S., Esumi S., Sendo T. Influence of lipopolysaccharide on diazepam-modified loss of righting reflex duration by pentobarbital treatment in mice. Eur. J. Pharmacol. 842: 231-238, 2019


  1. Higuchi T, Soga Y, Muro M, Kajizono M, Kitamura Y, Sendo T, Sasaki A.: Replacing zoledronic acid with denosumab is a risk factor for developing osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 125: 547-551, 2018
  2. Hagiya H, Koyama T, Zamami Y, Minato Y, Tatebe Y, Mikami N, Teratani Y, Ohshima A, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Tomono K, Kano MR. Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997-2016. Epidemiol Infect. Nov 9: 1-10. doi: 10.1017/S095026881800290X. 2018
  3. Nakamura Y., Kitamura Y., Sumiyoshi Y., Naito N., Kan S., Ushio S., Miyazaki I., Asanuma M., Sendo T. Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats. J. Pharmacol Sci. 138: 192-197, 2018
  4. Zamami Y., Kouno Y., Niimura T., Chuma M., Imai T., Mitsui M., Koyama T., Kayano M., Okada N., Hamano H., Goda M., Imanishi M., Takechi K., Horinouchi Y., Kondo Y., Yanagawa H., Kitamura Y., Sendo T., Ujike Y., Ishizawa K. The relationship between administration of nicardipine hydrochloride and development of delirium in patients on mechanical ventilation. Pharmazie 73: 740-743, 2018
  5. Teratani Y., Hagiya H., Koyama T., Adachi M., Ohshima A. Zamami Y., Tanaka H., Tatebe Y., Tasaka K., Mikami N., Shinomiya K., Kitamura Y., Kano M., Hinotsu S. Sendo T. Pattern of antibiotic prescriptions for outpatient acute respiratory tract infections in Japan, 2013–2015: A retrospective observational study. Family Practice Sep 29. doi: 10.1093/fampra/cmy094, 2018
  6. Esumi S., Kitamura Y., Yokota-Kumasaki H., Ushio S., Yamada-Takemoto A., Nagai R., Ogawa A., Kawasaki Y., Sendo T.: Effects of magnesium oxide on the serum duloxetine concentration and antidepressant-like effects of duloxetine in rats. Biol Pharma Bull 41: 1727-1731, 2018
  7. Onoue H., Koyama T., Zamami Y., Hagiya H., Tatebe Y., Mikami N., Shinomiya K., Kitamura Y., Hinotsu S., Sendo T., Ouchi Y., Kano M.: Trends in polypharmacy in Japan: a nationwide retrospective study. J Am Geriatr Soc. Oct 6. doi: 10.1111/jgs.15569, 2018
  8. Ichihara E., Hotta K., Kubo T., Higashionna T., Ninomiya K., Ohashi K., Tabata M., Maeda Y., Kiura K.: Clinical significance of repeat rebiopsy in detecting the EGFR T790M secondary mutation in patients with non-small cell lung cancer. Oncotarget 9: 29525-29531, 2018
  9. Torigoe H., Shien K., Takeda T., Yoshioka T., Namba K., Sato H., Suzawa K., Yamamoto H., Soh J., Sakaguchi M., Tomida S., Tsukuda K., Miyoshi S., Toyooka S.: Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations. Cancer Sci. Mar 13. doi: 10.1111/cas.13571, 2018
  10. Nishie H., Tetsunaga T., Kanzaki H., Oda K., Inoue S., Ryuo Y., Ota H., Miyawaki T., Arakawa K., Tetsunaga T., Kitamura Y., Sendo T., Morimatsu H., Ozaki T., Nishida K.: A multidisciplinary approach to the management of chronic pain through a self-managed behavioral exercise program: A pilot study in Japan. Acta Med. Okayama 72: 343-350, 2018
  11. Niimura T., Zamami Y., Imai T., Ito T., Sagara H., Hiroyuki H., Esumi S., Takechi K., Imanishi M., Koyama T., Amano M., Kurata N., Kitamura Y., Nakura H., Sendo T., Ishizawa K.: Administration of Kampo medicine through a tube at an advanced critical care center. J Med Invest. 65: 32-36, 2018
  12. Higuchi T., Soda Y., Muro M., Kajizono M., Kitamura Y., Sendo T., Sasaki A.: Replacing zoledronic acid with denosumab is a risk factor for developing osteonecrosis of the jaw. Surgery, Oral Medicine, Oral Pathology, Oral Radiology Mar 6. pii: S2212-4403(18)30081-6, 2018
  13. Yagi K., Shimada A., Sendo T.: Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia. Eur J Pharmacol 825: 28-33, 2018
  14. Takai M., Kawasaki Y., Arimoto, S., Tanimoto Y., Kitamura Y., Sendo T.: UV-irradiated 2-methyl-4′-(methylthio)-2-morpholinopropiophenone-containing injection solution produced frameshift mutations in the Ames mutagenicity assay. Environ Sci Pollut Res Feb 27. doi: 10.1007/s11356-018-1539-8, 2018
  15. Niimura T, Zamami Y, Imai T, Nagao K, Kayano M, Sagara H, Goda M, Okada N, Chuma M, Takechi K, Imanishi M, Koyama T, Koga T, Nakura H, Sendo T, Ishizawa K. Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit. J Pharm Pharm Sci. 21: 54-59, 2018
  16. Koyama T., Onoue H., Oshima A., Tanaka Y., Tatebe Y., Zamami Y., Shinomiya K., Kitamura Y. Trends in the medication reviews of community pharmacies in Japan: a nationwide retrospective study. International Journal of Clinical Pharmacy 40: 101-108, 2018


  1. Sato S., Zamami Y., Imai T., Tanaka S., Koyama T., Nimura T., Chuma M., Koga T., Takechi K., Kurata Y., Kondo Y., Izawa-Ishizawa Y., Sendo T., Nakura H., Isizawa K. Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia. Sci. Rep. 7(1):12683. doi: 10.1038/s41598-017-13073-0. 2017.
  2. Koyama T., Zamami Y., Oshima A., Teratani Y., Shinomiya K., Kitamura Y. Pattern of CT use in Japan, 2014: A nationwide cross-sectional study. Eur. J. Radiology 97: 96-100, 2017.
  3. Gomita Y, Esumi S, Kitamura Y, Motoda H, Sendo T, Sagara H, Araki H, Mio M, Inoue S, Kano Y. Intracranial self-stimulation and immobilization had different effects on neurite extension and the p38 MAPK pathway in PC12m3 cells. Life Sci. 190: 78-83, 2017.
  4. Tsuge M., Hazama K., Kanzaki H., Itano Y., Maeshima K., Oucida M., Nakatsuka H. Development of a novel analgesic for cancer pain targeting brain-derived neurotrophic factor.  Kawasaki Medical Journal  43: 107-120, 2017.
  5. Hirayama T., Nosaka N., Okawa Y., Ushio S., Kitamura Y., Sendo T., Ugawa T., Nakao A. AN69ST membranes adsorb nafamostat mesylate and affect the management of anticoagulant therapy: a retrospective study. J. Intensive Care 5:46 DOI 10.1186/s40560-017-0244-x
  6. Higuchi T., Inagaki M., Koyama T., Kitamura Y., Sendo T., Fujimori M., Kataoka H., Hayashibara C., Uchitomi Y., Yamada N. Emotional intelligence and its effect on pharmacist and pharmacy students with autistic-like traits. Am. J. Pharm. Educ. 71: 4 Article 74, 2017.
  7. Kudo K., Ohashi K., Makimoto G., Higo H., Kayatani H., Kurata Y., Takami Y., Minami D., Ninomiya T., Kubo T., Ichihara E., Sato A., Hotta K., Yoshino T., Tanimoto M., Kiura K. Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo. Mol. Oncol. doiI: 10.1002/1878-0261.12063, 2017
  8. Gomita Y, Esumi S, Sugiyama N, Kitamura Y, Koike Y, Motoda H, Sendo T, Kano Y. Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway. Neurosci. Lett. 649: 78-84, 2017
  9. Kawaura A., Kitamura Y., Tanida N., Akiyama J., Mizutani M., Harada K., Morishita M., Inoue S., Kano Y., Okano T., Takeda E. Antidepressant-like effect of 1α-hydroxyvitamin D3 on mice in the forced swimming test. J. Nutr. Sci. Vitaminol. 63: 81-84, 2017
  10. Kitamura Y., Kanemoto E., Sugimoto M., Machida A., Nakamura Y., Naito N., Kanzaki H., Miyazaki I., Asanuma M., Sendo T. Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats. Naunyn Schmiedebergs Arch Pharmacol. 390: 369-378, 2017
  11. Kikkawa A., Kitamura Y., Aiba T., Hiraki K., Sendo T. Correlation between the efficacy of lamotrigine and the serum lamotrigine level during the remission phase of acute bipolar II depression: A naturalistic and unblinded prospective pilot study. Biol. Pharm. Bull. 40: 413-418, 2017
  12. Takeda T., Yamamoto H., Kanzaki H., Suzawa K., Yoshioka T., Tomida S., Cui X., Murali R., Namba K., Sato H., Torigoe H., Watanabe M., Shien K., Soh J., Asano H., Tsukuda K., Kitamura Y., Miyoshi S., Sendo T., Toyooka S. Yes1 signaling mediates the resistance to trastuzumab/lapatinib in breast cancer. PLOS ONE 12(2):e0171356. doi: 10.1371/journal.pone.017135, 2017.
  13. Matsuyama A., Takatori S., Sone Y., Ochi E., Goda M., Zamami Y., Hashikawa-Hobara N., Kitamura Y., Kawasaki H. Effect of nerve growth factor on innervation of perivascular nerves in neovasculatures of mouse cornea. Biol. Pharm. Bull. 40: 396-401, 2017
  14. Sone Y., Takatori S., Ochi E., Zamami Y., Matsuyama A., Fukuhara S., Goda M., Kitamura Y., Kawasaki H. Nerve Growth Factor Facilitates the Innervation of Perivascular Nerves in Tumor-Derived Neovasculature in the Mouse Cornea. Pharmacology 99: 57-66, 2017


  1. Isozaki H, Hotta K, Ichihara E, Takigawa N, Ohashi K, Kubo T, Ninomiya T, Ninomiya K, Oda N, Yoshioka H, Ichikawa H, Inoue M, Takata I, Shibayama T, Kuyama S, Sugimoto K, Harada D, Harita S, Sendo T, Tanimoto M, Kiura K. Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non-Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405). Clin Lung Cancer 17: 602-605, 2016
  2. Zamami Y, Imai T, Imanishi M, Takechi K, Shiraishi N, Koyama T, Sagara H, Shiino Y, Nakura H, Sendo T, Ishizawa K. Evaluation of a Pharmaceutical Life-saving Skills Training Program using the Customer Satisfaction Analysis. Journal of Pharmaceutical Health Care and Sciences 2:21, 2016 DOI 10.1186/s40780-016-0054
  3. Ishida H., Kanamitsu K., Washio K., Muraoka M., Sakakibara K., Matsubara T., Kanzaki H., Shimada A. Relapsed infant MLL-rearranged acute lymphoblastic leukemia with additional genetic alterations. Pediatr Blood Cancer 2016 DOI 10.1002/pbc.26100
  4. Isozaki H, Ichihara E, Takigawa N, Ohashi K, Ochi N, Yasugi M, Ninomiya T, Yamane H, Hotta K, Sakai K, Matsumoto K, Hosokawa S, Bessho A, Sendo T, Tanimoto M, Kiura K. Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases. Cancer Res. 76: 1506-1516, 2016
  5. Higuchi Y, Inagaki M, Koyama T, Kitamura Y, Sendo T, Fujimori M, Uchitomi Y, Yamada N. A cross-sectional study of psychological distress, burnout, and the associated risk factors in hospital pharmacists in Japan. BMC Public Health. 6:534, 2016
  6. Tsuboi C., Kawasaki Y., Yoshitome K., Yagi K., Miura T., Esumi S., Miyazaki I., Asanuma M., Kitamura Y., Sendo T. In vitro quantitative determination of the concentration of the polymerization agent methyl 2-benzoylbenzoate in intravenous injection solution and the cytotoxic effects of the chemical on normal human peripheral blood mononuclear cells. Environ Sci Pollut Res 23: 10262-10269, 2016
  7. Miyazaki I., Murakami S., Torigoe N., Kitamura Y., Asanuma M. Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian model mice. J. Neurochem. 136: 194-204, 2016
  8. Kanzaki H., Mukhopadhya NK., Cui X, Ramanujan VK., Murali R. Trastuzumab-Resistant Luminal B Breast Cancer Cells Show Basal-Like Cell Growth Features Through NF-κB-Activation. Monoclon Antib Immunodiagn Immunother. 35: 1-11, 2016


  1.  Murakawa K., Kitamura Y., Watanabe S., Hongo S., Shinomiya K., Sendo T.:  Clinical Risk Factors Associated with Postoperative Delirium and Evaluation of Delirium Management and Assessment Team in Surgical Patients. Journal of Pharmaceutical Health Care and Sciences 1:4 (2015) DOI 10.1186/s40780-014-0002-3
  2. Kajizono M., Aoyagi M., Kitamura Y., Sendo T. Effectiveness of the medical supportive team for outpatients treated with sorafenib. Journal of Pharmaceutical Health Care and Sciences 1:6 (2015) DOI 10.1186/s40780-014-0005-0
  3. Kurata Y., Miyauchi N., Suno M., Ito T., Sendo T., Kiura K. Correlation of plasma crizotinib trough concentration with adverse events in patients with anaplastic lymphoma kinase positive non-small-cell lung cancer. Journal of Pharmaceutical Health Care and Sciences 1:8 (2015) DOI 10.1186/s40780-014-0008-x
  4. Kawasaki Y., Tuboi C., Yagi K., Morizane M., Masaoka Y., Esumi S., Kitamura Y., Sendo T.. Photoinitiators enhanced 1,2-dichloropropane-induced cytotoxicity in human normal embryonic lung fibroblasts cells in vitro. Environmental Science and Pollution Research 22: 4763-4770, 2015
  5. Suno M., Endo Y., Nishie H., Kajizono M., Sendo T., Matsuoka J. Refractory cachexia is associated with increased plasma concentrations of fentanyl in cancer patients. Therapeutics and Clinical Risk Management. 11: 751-757, 2015
  6. Tsutsui R., Shinomiya K., Sendo T., Kitamura Y., Kamei C. Effects of the 5-HT1A receptor agonist tandospirone on ACTH-induced sleep disturbance in rats. Biol. Pharm. Bull. 38: 884-888, 2015
  7. Kitamura Y., Hattori S., Yoneda S., Watanabe S., Kanemoto E., Sugimoto M., Kawai T., Machida A., Kanzaki H., Miyazaki I., Asanuma M., Sendo T. Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation. Behav. Brain Res. 292: 184-193, 2015
  8. Hagiya H., Tasaka K., Sendo T., Otsuka F. Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection. Infect Drug Resist. 8: 353-357, 2015
  9. Kajizono M., Sada H., Sugiura Y., Soga Y., Kitamura Y., Matsuoka J., Sendo T. Incidence and risk factors of osteonecrosis of the jaw in advanced cancer patients after treatment with zoledronic acid or denosumab: a retrospective cohort study. Biol. Pharm. Bull. 38: 1850-1855, 2015
  10. Higuchi Y., Uchitomi Y., Fujimori M., Koyama T., Kataoka H., Kitamura Y., Sendo T., Inagaki M. Exploring autistic-like traits relating to empathic attitude and psychological distress in hospital pharmacists. Int. J. Clin. Pharm. 37: 1258-1266、2015
  11. Morizane M., Kawasaki Y., Miura T., Yagi K., Esumi S., Kitamura Y., Sendo T. Photoinitiator-initiated estrogenic activity in human breast cancer cell line MCF-7. J. Toxicol. Environ. Health A. 78: 1450-1460, 2015


  1. Onoue Y., Kuwatsuka K., Miyazaki I., Asanuma M., Kitamura Y., Sendo T.:  Effects of bupropion and pramipexole on cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats. Biol. Pharm. Bull 37: 327-330, 2014
  2. Yagi K., Kawasaki Y., Nakamura H., Miura T., Esumi S., Matsunaga H., Kitamura Y., Sendo T.. Differential synergistic effect of COX inhibitors on cell survival suppressed by Sorafenib in hepatocellular cancer cells. Biol. Pharm. Bull. 37: 1234-1240, 2014
  3. Miyake A., Kitamura Y., Miyazaki I., Asanuma M., Sendo T. Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats. Pharmacol. Biochem, Behav. 122: 240-245, 2014
  4. Tomotsuka N., Kaku R., Obata N., Matsuoka Y., Kanzaki H., Taniguchi A., Muto N., Omiya H., Itano Y., Sato T., Ichikawa H., Mizobuchi S., Morimatsu H. Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model. J. Pain Res. 7: 415-423, 2014
  5. Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K. A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene. Jpn. J. Clin. Oncol. 44: 963-968, 2014
  6. Kitamura Y, Hayashi H, Onoue Y, Kuwatsuka K, Miyake A, Miyazaki I, Asanuma M, Sendo T. Effects of imipramine and lithium on the expression of hippocampal Wnt 3a and cyclin D1 in ACTH-treated rats. Journal of Behavioral and Brain Sciences 4: 483-490, 2014


  1. Murakawa K., Sato T., Maeda Y., Kitamura Y., Tanimoto M., Sendo T. Preparation of Enteric-coated Capsules of Beclomethasone Dipropionate for Patients with Intestinal Graft-Versus-Host Disease and a Case Study. Acta Med Okayama 67: 319-324, 2013
  2. Kuwatsuka K., Hayashi H., Onoue Y., Miyazaki I., Koyama T., Asanuma M., Kitamura Y., Sendo T. The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats. J. Pharmacol. Sci. 122: 34-41, 2013
  3. Kawasaki Y., Yagi K., Tsuboi C., Morizane M., Kitamura Y., Sendo T. The polymerization agent, 2-methyl-4’-(methylthio)-2-morpholinopropiophenone induces caspases-3/7 in human blood mononuclear cells in vitro. Biol. Pharm. Bull. 36: 1640-1645, 2013
  4. Miyazaki I., Asanuma M., Murakami S., Takeshima M., Torigoe N., Kitamura Y. Miyoshi, K. Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models. Neurobiol. Dis. 59:244-256, 2013
  5. Esumi S., Kawasaki Y., Nakamoto A., Sagara H., Kitamura Y., Gomita Y., Sendo T. : Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation Eur. J. Pharmacol. 720:186-191、2013
  6. Li B, Suemaru K., Kitamura Y., Gomita Y., Araki H., Cui R. Imipramine-induced c-Fos expression in the medial prefrontal cortex is decreased in the ACTH-treated rats. J. Biochem. Molecular Toxicology  27:486-491, 2013
  7. Esumi S, Sagara H, Nakamoto A, Kawasaki Y, Gomita Y, Sendo T. Effect of GBR12909 on affective behavior: distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation. Behav Brain Res. 243: 313-321, 2013


  1. Kawasaki Y., Yamaji K., Matsunaga H., Sendo T.: Cytotoxicity of the Polymerization Agent, 2-Methyl-4′-(methylthio)-2-morpholinopropiophenone on Human Monocytes. Biol. Pharm. Bull, 35(2):256-9, 2012.
  2. Tamaki C., Nawa H., Takatori S., Oda S., Sendo T., Zamami Y., Y., Kawasaki H.: Anandamide induces endothelium-dependent vasoconstriction and CGRPergic nerve-mediated vasodilation in the rat mesenteric vascular bed. J. Pharmacol. Sci. 118(4):496-505, 2012.
  3. Ishihara M., Ikesue H., Matsunaga H., Suemaru K., Kitaichi K., Suetsugu K., Oishi R., Sendo T., Araki H., Itoh Y., A multi-institutional study evaluating the effects of laxatives and antiemetics for preventing opioid-induced adverse events. Clin. J. Pain. 28(5):373-381, 2012.
  4. Jobu K., Sun C., Yoshioka S., Yokota J., Onogawa M., Kawada C., Inoue K., Shuin T., Sendo T., Miyamura M. : Metabonomic study on the biochemical profiles of odor elements in urine of human bladder cancer., Biol. Pharm. Bull. 35(4):639-42, 2012.
  5. Kajizono M., Saito M., Maeda M., Yamaji K., Fujiwara S., Kawasaki Y., Matsunaga H., Sendo T.: Cetuximab-induced skin reactions are suppressed by cigarette smoking in patients with advanced colorectal cancer. Int J Clin Oncol, in press, 2012
  6. Yamaji K., Kawasaki Y., Yoshitome K., Matsunaga H., Sendo T.: Quantitation and cytotoxicity on human monocytes of 1-hydroxycyclohexy-phenyl ketone (Irgacure 184) in water injection between three brands. Biol. Pharm. Bull. 35(10): 1821-1825, 2012
  7. Ohnishi J, Miyake A, Kuwatsuka K, Onoue Y, Lee M, Koyama T, Sendo T, Kawasaki H, Kitamura Y.: Effect of pharmacist management on serum hemoglobin levels with renal anemia in hemodialysis outpatients. Biol Pharm Bull. 34: 1609-1612, 2012


  1. Ueshima, S., Aiba, T., Sato, T., Matsunaga, H., Kurosaki, Y., Ohtsuka,Y. and Sendo,
    T. Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development.
    Biol. Pharm. Bull., 34(1): 108-113, 2011
  2. Kawasaki Y, Araki H, Suemaru K, Kitamura Y, Gomita Y, Sendo T.: Involvement of dopaminergic receptor signaling in the effects of glutamatergic receptor antagonists on conditioned place aversion induced by naloxone in single-dose morphine-treated rats. J Pharmacol Sci. 117: 27-33, 2011.
  3. Kawasaki Y, Ishida S, Jin C, Kitamura Y, Kawasaki H, Gomita Y, Sendo T, Araki H.: Effect of glutamate receptor antagonists microinjected into the nucleus accumbens on place aversion induced by naloxone in single-dose, morphine-treated rats. Eur J Pharmacol. 666: 131-134, 2011
  4. Hayashi K, Ueshima S, Ouchida M, Mashimo T, Nishiki T, Sendo T, Serikawa T, Matsui H, Ohmori I.: Therapy for hyperthermia-induced seizures in Scn1a mutant rats. Epilepsia. 52: 1010-1017, 2011
  5. Kitamura Y, Doi M, Kuwatsuka K, Onoue Y, Miyazaki I, Shinomiya K, Koyama T, Sendo T, Kawasaki H, Asanuma M, Gomita Y. Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats. Biol Pharm Bull. 34: 77-81, 2011
  6. Ishida S, Kawasaki Y, Araki H, Asanuma M, Matsunaga H, Sendo T, Kawasaki H, Gomita Y, Kitamura Y. : α7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine. Psychopharmacology 214: 923-931, 2011


  1. Doi M, Miyazaki I, Nagamachi T, Shinomiya K, Matsunaga H, Sendo T, Kawasaki H, Asanuma M, Gomita Y, Kitamura Y. : Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats. Acta Med Okayama. 64: 219*223, 2010.


  1. Ueshima, S., Aiba, T., Ishikawa, N., Sato, T., Kawasaki, H., Kurosaki, Y., Ohtsuka, Y. and Sendo, T.: Poor applicability of estimation method for adults to calculate unbound serum concentrations of valproic acid in epileptic neonates and infants. J. Clin. Pharm. Ther, 34: 415-422, 2009
  2. Kitagawa K, Kitamura Y, Miyazaki T, Miyaoka J, Kawasaki H, Asanuma M, Sendo T, Gomita Y. : Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 380: 59-66, 2009.


  1. Kawasaki, Y., Matsuka, N., Okada, T., Kawashima, R., Kitagawa, N., Sendo, T. and Gomita, T. :Examination of particulate contamination after ampoule opening- Relationship between ampoule inner-diameter and glass particle accumulation after opening-. Jpn. J. Pharm. Health. Care Sci. 34(11): 1032-1036, 2008
  2. Maiguma, T., Hayashi, Y., Ueshima, S., Kaji, H., Egawa, T., Chayama, K., Morishima, T., Kitamira, Y., Sendo, T., Gomita, Y. and Teshima, D.: Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia. Int J. Clin Pham. Ther., 46(11): 584-590, 2008
  3. Ishii, M., Kawakami, Y., Date, H., Higaki, K., Sendo, T and Kimura, T.: Correlation of cyclosporine blood concentration-dose ratio and biochemical parameters in living-donor lung transplant patients. Jpn. J. Pharm. Health. Care Sci., 34: 381-385, 2008
  4. Ueshima, S., Aiba, T., Makita, T., Nishihara, S., Kitamura, Y., Kurosaki,Y., Kawasaki, H., Sendo, T., Ohtsuka Y. and Gomita. Y.: Characterization of nonlinear relationship between total and unbound serum concentration of valproic acid in epileptic children. J. Clin. Pharm. Ther, 33: 31-38, 2008
  5. Sagara H, Kitamura Y, Esumi S, Sendo T, Araki H, Gomita Y.: Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. Acta Med Okayama. 62: 227-233, 2008
  6. Sagara H, Kitamura Y, Sendo T, Araki H, Gomita Y.: Effect of diazepam on the runway method using priming stimulation of intracranial self stimulation behavior. J Pharmacol Sci. 107: 355-360, 2008
  7. Sagara H, Kitamura Y, Sendo T, Araki H, Gomita Y.:

    Motivational effect of nomifensine in the intracranial self-stimulation behavior using a runway method.Biol Pharm Bull. 31: 1036-1040, 2008

  8. Kitamura Y, Kitagawa K, Kimoto S, Sagara H, Shibata K, Kawasaki H, Sendo T, Gomita Y.: Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats. J Pharmacol Sci. 106: 639-644, 2008
  9. Sagara H, Kitamura Y, Sendo T, Araki H, Gomita Y.: Motivational effects of methamphetamine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. Biol Pharm Bull. 34: 541-545, 2008
  10. Hozumi H, Asanuma M, Miyazaki I, Fukuoka S, Kikkawa Y, Kimoto N, Kitamura Y, Sendo T, Kita T, Gomita Y.:

    Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. Toxicol Lett. 177: 123-129, 2008

  11. Kitamura Y, Akiyama K, Kitagawa K, Shibata K, Kawasaki H, Suemaru K, Araki H, Sendo T, Gomita Y.: Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? Pharmacol Biochem Behav. 89: 235-240, 2008
  12. Kitamura Y, Fujitani Y, Kitagawa K, Miyazaki T, Sagara H, Kawasaki H, Shibata K, Sendo T, Gomita Y.: Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA. Biol Pharm Bull. 31: 246-249, 2008
  13. Kitamura Y, Shibata K, Akiyama K, Kimoto S, Fujitani Y, Kitagawa K, Kanzaki H, Ouchida M, Shimizu K, Kawasaki H, Sendo T, Gomita Y.:

    Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex. J Pharmacol Sci. 106: 100-106, 2008

  14. Hamano R, Takahashi HK, Iwagaki H, Kanke T, Liu K, Yoshino T, Sendo T, Nishibori M, Tanaka N.:

    Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells. Shock 29: 154-159, 2008


  1. Takahashi HK, Kanke T, Liu K, Yoshino T, Sendo T, Tanaka N, Nishibori M.: Adenosine A2A-receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 production in monocytes. J Pharmacol Sci. 104: 183-186, 2007
  2. Kitamura Y, Akiyama K, Hashimoto S, Kitagawa K, Kawasaki H, Shibata K, Shinomiya K, Suemaru K, Araki H, Sendo T, Gomita Y.: Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats. Eur J Pharmacol. 566: 113-116, 2007
  3. Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H, Yagi T, Yoshino T, Sendo T, Tanaka N, Nishibori M.: Effect of adenosine receptor subtypes stimulation on mixed lymphocyte reaction. Eur J Pharmacol. 564: 204-210, 2007


  1. Kawakami Y, Kitamura Y, Araki H, Kitagawa K, Suemaru K, Shibata K, Gomita Y.
    Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats. Pharmacol Biochem Behav. 2005, 81(1): 65-70.
  2. Motoshima S, Suemaru K, Kawasaki Y, Jin C, Kawasaki H, Gomita Y, Araki H.
    Effects of alpha4beta2 and alpha7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats. Eur J Pharmacol. 2005, 519(1-2): 91-95.


  1. Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M.: Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci. 92: 420-423, 2003